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Publications

Publications (since 2006): 

1.      Tyrrell, J. Whelan, N, Wright, C, Sa-Correia, I.  McClean, S.  Thomas, M.  Callaghan, M.  Investigations of the multifaceted iron acquisition strategies of Burkholderia cenocepacia.  Biometals 2015 (2):367-80. doi: 10.1007/s10534-015-9840-1.PMID: 25725797

2.       Costello, A, Reen, FJ, O’Gara F, Callaghan, M and McClean S.  Inhibition of co-colonising cystic fibrosis-associated pathogens by Pseudomonas aeruginosa and Burkholderia multivorans.  Microbiology 2014 160, 1474-1487.  PMID: 24790091

3.       Olszak, T., Zarnowiec, P., Kaca, W,  Danis-Wlodarczyk K, Augustyniak, D, Drevinek P,  de Soyza A, McClean S, Drulis-Kawa Z.In vitro and in vivo antibacterial activity of environmental bacteriophages against Pseudomonas aeruginosa strains from Cystic Fibrosis patients. App Micro Biotech.   2015 99(14):6021-33.  PMID: 25758956

4.       Ferreira, AS Silva, I, Fernandes, F, Pilkington, R, Callaghan, M, McClean,S,  Moreira LM.   The tyrosine kinase BceF and the phosphotyrosine phosphatase BceD of Burkholderia contaminans are required for efficient invasion and epithelial disruption of a cystic fibrosis lung epithelial cell line Infect. Immun.   2015, 83(2):812-21.PMID: 25486990

5.       O’Hara, T, Seddon, B, McClean, S and Dempsey, E.  TOXOR: Design and Application of an Electrochemical Toxicity Biosensor for Environmental Monitoring.  Electroanalysis. 2014 27 (1), 58-66.   doi/10.1002/elan.201400433l

6.       Shinoy M, Dennehy, R, Coleman, L, Carberry, S, Schaffer, K, Callaghan, M, Doyle, S, McClean, S.  Immunoproteomic analysis of the proteins expressed by two related pathogens, Burkholderia multivorans and Burkholderia cenocepacia during human infection. PLOS One 2013 Nov 15;8(11):e80796. PMID: 24260482

7.       Sullivan, M.  Foltyn-Arfa Kia, A, Long, M, Walsh, M, Kavanagh, K, McClean, S, Creaven, BS.  Isolation and characterisation of silver(I) complexes of substituted coumarin-4-carboxylates which are effective against Pseudomonas aeruginosa biofilms. Polyhedron 2014, 67, 549-449.

8.       Madeira A, Dos Santos SC, Santos PM, Coutinho CP, Tyrrell J, McClean S, Callaghan M, Sá-Correia I. Proteomic Profiling of Burkholderia cenocepacia clonal isolates with different virulence potential retrieved from a cystic fibrosis patient during chronic colonisation.  Plos One, (2013) 8(12) e83065. PMID: 24349432

9.       B Schaible, S McClean, A Selfridge, A Broquet, K Asehnoune, CT Taylor, K Schaffer.  Hypoxia modulates infection of epithelial cells by P. aeruginosa.  PLoS One.  2013 8(2) e56491 PMID: 23418576

10.   De Soyza A, Hall AJ, Mahenthiralingam E, Drevinek P, Kaca W, Drulis-Kawa Z, Stoitsova SR, Toth V, Coenye T, Zlosnik JE, Burns JL, Sá-Correia I, De Vos D, Pirnay JP, Kidd TJ, Reid D, Manos J, Klockgether J, Wiehlmann L, Tümmler B, McClean S, Winstanley C; EU FP7 funded COST Action BM1003 “Cell surface virulence determinants of cystic fibrosis pathogens”.  Developing an international P. aeruginosa reference panel. MicrobiologyOpen   2013 Dec;2(6):1010-23.  PMID: 24214409

11.   E Wilcz-Villega, S McClean, M O’Sullivan Reduced E-cadherin expression in irritable bowel syndrome is associated with abdominal pain and symptom duration.  Neurogastroenterol Motil. 2014, 26(3):316-25.    PMID:  24286617

12.   E Wilcz-Villega, S McClean, M O’Sullivan.  Mast Cell Tryptase Reduces Junctional Adhesion Molecule-A (JAM-A) Expression in Intestinal Epithelial Cells: Implications for the Mechanisms of Barrier Dysfunction in Irritable Bowel Syndrome.  Am J Gastroenterol.  2013 108 (7) 1140-51 PMID: 23588236

13.   *C Wright, R Leyden, PV Murphy, M Callaghan, T Velasco-Torrijos, S McClean.  Inhibition of Burkholderia multivorans adhesion to lung epithelial cells by bivalent lactosides.  Molecules 2012 17(9) 10065-10071. PMID: 22922277

14.   Kellett, O Howe, M O’Connor, M McCann, BS Creaven, S McClean, A Foltyn-Arfa-Kia, A Casey, M Devereux.  Radical-induced DNA damage by cytotoxic square planar copper (II) complexes incorporating o-phthalate and 1,10 phenothroline or 2,2’-dipyridyl.  Free Radic Biol Med. 2012 53(3) 564-576.  PMID: 22659117

15.   *A. Bevivino, L. Pirone, R. Pilkington, N. Cifani, C. Dalmastri, M. Callaghan, F. Ascenzioni, S. McClean. Interaction of environmental B. cenocepacia strains with cystic fibrosis and non-cystic fibrosis bronchial epithelial cells in vitro.  Microbiology 2012 May;158(Pt 5):1325-33. PMID: 22322958

16.   F.Di Lorenzo, A. Silipo, A Costello, L Sturiale, D Garozzo, M. Callaghan, R. Lanzetta, M. Parrilli, S. McClean, A. Molinaro. Structural study of the novel lipopolysaccharide O-antigen produced by the emerging cystic fibrosis pathogen Pandoraea pulmonicola. Eur J Org. Chem. 2012, 2012, (11) 2243–2249. abstract

17.   M. O'Connor, A. Kellett, M. McCann, … S. McClean,  A.Foltyn-Arfa Kia,    D. O’Shea, M. Devereux  Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities display promising chemotherapeutic potential with fast acting in-vitro cytotoxicity against cisplatin sensitive and resistant cancer cell lines.  J. Med. Chem., 2012, 55 (5), pp 1957–1968PMID: 22313179

18.   C Wright, R Pilkington, M. Callaghan, S. McClean.  Activation of MMP-9 by human lung epithelial cells in response to the cystic fibrosis associated  B. cenocepacia, reduced wound healing in vitro.  2011;301(4):L575-86 PMID: 21743026

19.   Costello, G. Herbert, L. Fabumni, K. Schaffer, K. Kavanagh, E. Caraher, M. Callaghan,  S. McClean.  Virulence of emerging respiratory pathogen, genus Pandoraea, in vivo and its interactions with lung epithelial cells.  2011 J. Med. Micro  60:289-99 PMID: 21127160

20.   Kellett, M. McCann, M. O’Connor, M. McNamara, P. Lynch, G. Rosair, V. McKee, B. Creaven, M. Walsh, S. McClean, A. Foltyn, D. O’Shea, O. Howe, M.Devereux. Bis-Phen-anthroline copper(II) phthalate complexes are potent antitumour agents with ‘self-activating’ metallonuclease and DNA Binding Properties.  Dalton Trans 40(5):1024-7.  PMID: 21165464

21.   Mullen, M.Callaghan, S. McClean. Invasion of Burkholderia cepacia complex isolates into lung epithelial cells involves glycolipid receptors.  Microb Path. 49:381-387 (2010)

22.   Creaven BS, Czeglédi E, Devereux M, Enyedy EA, Foltyn-Arfa Kia A, Karcz D, Kellett A, McClean S, Nagy NV, Noble A, Rockenbauer A, Szabó-Plánka T, Walsh M.   Biological activity and coordination modes of copper(ii) complexes of Schiff base-derived coumarin ligand.  Dalton Trans 2010  39(45):10854-65.  PMID: 20949224

23.   Wright, C., Herbert, G, Pilkington, R, Callaghan, M, McClean, S.  Real-time PCR method for the quantification of Burkholderia cepacia complex attached to lung epithelial cells and inhibition of that attachment., Lett Applied Micro. 50 (2010): 500-506PMID: 20337933

24.   McKeon, S, McClean, S., Callaghan, M. Burkholderia cepacia complex (Bcc) interactions with alveolar macrophages in vitro.  FEMS Immunol. Med. Microbiol.(2010) 60(1):36-43.PMID: 20602636

25.   SK. Kumar, S. McClean, M. Callaghan. IL-8 released from human lung epithelial cells induced by cystic fibrosis pathogens Burkholderia cepacia complex affects growth and intracellular survival of bacteria. Int. J. Med. Microbiol.  (2011) 301 (1): 26-33. PMID: 20829108

26.   S. Maher, M. Devocelle, S. Ryan, S. McClean, DJ Brayden. Impact of amino acid replacements on in vitro  permeation enhancement and cytotoxicity of the intestinal absorption promoter, melittin.  Int. J Pharma 387 (2010) 154–160;   PMID: 20025949

27.   Creaven, BS, Devereux, M, Foltyn, A, McClean, S, Rosair, G, Reddy Thangella, V,  Walsh, M.  Quinolin-2(1H)-one-triazole derived Schiff bases and their Cu(II) and Zn(II) complexes: Possible new therapeutic agents. Polyhedron (2010) 29 (2), 813-822

28.   Maher, S., Vilk, G., Kelleher, F., Lajoie, G., McClean, S.  Chemical Modification of the Carboxyl Terminal of Nisin A with Biotin does not Abolish Antimicrobial Activity against the indicator organism, K. rhizophilaInt J Pept Res Therap.15:3  219-226 2009

29.   S. Maher, X. Wang, V, Bzik, S. McClean and D.J. Brayden Evaluation of intestinal absorption and mucosal toxicity using two promoters. II. Rat Instillation and perfusion studies.   Eur. J. Pharma. Sci. 38 ( 4), 2009, pp. 291 – 300 PMID: 19664704

30.   Maher, S. McClean, S.  Melittin exhibits necrotic cytotoxicity in gastrointestinal cells which is attenuated by cholesterol   (2008) Biochem. Pharmacol.75(5):1104-14.  PMID: 18068148

31.   Caraher E, Collins J, Herbert G, Murphy PG, Gallagher CG, Crowe MJ, Callaghan M, McClean S.  Evaluation of in vitro virulence characteristics of the genus Pandoraea in lung epithelial cells.  J Med. Microbiol (2008)  57(Pt 1):15-20  PMID: 18065662

32.   Mullen T, Markey K, Murphy P, McClean S, Callaghan M. Role of lipase in Burkholderia cepacia complex (Bcc) invasion of lung epithelial cells.  Eur J Clin Microb Infect Dis. 2007  26(12):869-77 PMID: 17874328

33.   Caraher, EM, Gumulapurapu, K,  Taggart, CC, McClean, S, Callaghan, M.  The effect of recombinant human lactoferrin on growth and the antibiotic susceptibility of the CF pathogen Burkholderia cepacia complex when cultured planktonically or as biofilms.  J Antimicrobial Chemotherapy.  2007  60(3):546-54PMID: 17595284

34.   Maher, S., Feighery, L., Brayden DJ, McClean S.  Melittin as an epithelial permeability enhancer I: Investigation of its mechanism of action in Caco-2 monolayers. (2007)  Pharm Res, 24: 1336-1345. PMID: 17373574

35.   Maher, S., Feighery, L., Brayden DJ, McClean S.  Melittin as a permeability enhancer II: in vitro investigations in human mucus secreting intestinal monolayers and rat colonic mucosae.  (2007), Pharm Res,  24: 1346-56. PMID: 17380268

36.   Caraher E, Reynolds G, Murphy P, McClean S, Callaghan M.  Comparison of antibiotic susceptibility of Burkholderia cepacia complex organisms when grown planktonically or as biofilm in vitro. Eur J Clin Microbiol Infect Dis. 2007; 26(3):213-6. PMID: 17265071

37.   Duff C, Murphy PG, Callaghan M, McClean S.  Differences in invasion and translocation of Burkholderia cepacia complex species in polarised lung epithelial cells in vitro. Microb Pathog. 2006 Oct-Nov;41(4-5):183-92. PMID: 16938423

38.   Caraher E, Duff C, Mullen T, Mc Keon S, Murphy P, Callaghan M, McClean S.  Invasion and biofilm formation of Burkholderia dolosa is comparable with Burkholderia cenocepacia and Burkholderia multivorans. J Cyst Fibros. 2007 Jan;6(1):49-56 PMID:16781896

39.   Maher S, McClean S.  Investigation of the cytotoxicity of eukaryotic and prokaryotic antimicrobial peptides in intestinal epithelial cells in vitro. Biochem Pharmacol. 2006 Apr 28;71(9):1289-98. PMID: 16530733

Reviews: 

1.  Casey, WT and McClean S.  Exploiting molecular virulence determinants in Burkholderia  to develop vaccine antigens.  Curr Med Chem  2015;22(14):1719-33.  PMID: 25850766

2.  Cullen, L and McClean S.  Bacterial adaptation during chronic respiratory infections.  Pathogens, 2015, 2015 Mar 2;4(1):66-89 PMID: 25738646

3.  McGuigan L, Callaghan M.  The evolving dynamics of the microbial community in the cystic fibrosis lung.  Environ Microbiol. 2015:  17(1):16-28. doi: 10.1111/1462-2920.12504.  PMID: 24801013

4.  Dennehy R. and McClean S.  Immunoproteomics: the key to discovery of new vaccine antigens against bacterial respiratory infections.  Curr. Protein Pept Sci 2012.  12(8) 807-815  PMID: 23305366

5.  Callaghan M and McClean S.  Bacterial host interactions in cystic fibrosis.  (2012) Current Opinion Micro.  15: 71-77. PMID: 22137884

6.  McClean S.  Eight stranded β-barrel and related outer membrane proteins:   Role in bacterial pathogenesis.   in Cell Processes in Bacterial diseases:   A molecular view.  (2012) Rita Berisio (Editor) Protein & Peptide letters.  2012 19(10):1013-25.  PMID: 22533621

7.  McClean, S and Callaghan, M.  Burkholderia cepacia complex:  Epithelial cell-pathogen confrontations and potential for therapeutic intervention. J. Med Micro.  58(Pt 1):1-12. (2009)  PMID: 19074648

8.  Maher, S., Feighery, L., Brayden DJ, McClean S. Cracking the junction: Update on the progress of gastrointestinal absorption enhancement in the delivery of poorly absorbed drug.   Crit. Rev Therap Drug Carrier Systems.  (2008) 25 (2) 117-168  PMID: 18540837

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